The more closely related the father (sire) and the mother (dam) of a dog are, the more inbreeding there is.

This is the 4 generations Pedigree of Anisette de Moreau, a highly inbred Sloughi
the result of a brother x sister mating.
This pedigree has a very high Coefficient of Inbreeding of 25.78%
Such matings are not a good idea to preserve good health in a breed
and result often in increasing the risk for genetic diseases.

      Parents                                          Grandparents                                      Great Grandparents                             Great great Grandparents